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Cloxacillin

Synonyms: Orbenin

Cloxacillin marketed as Cloxapen, Orbenin, Tegopen.

Cloxacillin sodium is bactericidal and binds to specific penicillin-binding proteins on the bacterium and inhibits the transpeptidation of enzyme, thereby preventing the cross-linking of peptidoglycans. This leads to an interruption of synthesis of the bacterial cell wall and causes bacterial lysis or cell death.
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Cloxacillin is a semi-synthetic penicillin, resistant to penicillinase, and is therefore active against penicillinase-producing or beta-lactamase producing staphylococci, Cloxacillin is in general less effective against organisms susceptible to benzylpenicillin, such as streptococci, pneumococci and non-penicillinase-producing staphylococci, and is not useful against gram-negative bacteria.

Indications:

Cloxacillin is indicated for the treatment of infections due to penicillinase-producing staphylococci that are resistant to benzylpenicillin. It is used against gram-positive staphylococcus aureus in: skin and soft tissue infections, pneumonia, endocarditis and osteomyelitis

How to take:

One 500 mg capsule six hourly, administered one hour before meals. Please see label. For more detailed information please consult specialist. Do not take more of Cloxacillin Cap, than it is indicated at the label without consulting your doctor.

Precautions:

Do not violate instructions. Report symptoms of adverse effect. Use with caution in patients with a known history of allergy to penicillins, anaphylactic shock may occur.

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