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Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Metoclopramide increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter.
The antiemetic properties of Metoclopramide appear to be a result of its antagonism of central and peripheral dopamine receptors. Dopamine produces nausea and vomiting by stimulation of the medullary chemoreceptor trigger zone (CTZ), and Metoclopramide blocks stimulation of the CTZ by agents like l-dopa or apomorphine which are known to increase dopamine levels or to possess dopamine-like effects. Metoclopramide also abolishes the slowing of gastric emptying caused by apomorphine.

Indications:

Nausea, vomiting, gastro-intestinal disorders dyspepsia-like.

How to take:

The usual dosage for adults is 1 tablet 3-4 times daily before meals. Please see label. For more detailed information please consult specialist. Do not take more of. Metoclopramide tab than it is indicated at the label without consulting your doctor.

Precautions:

Do not violate instructions. Report adverse effects: restlessness, drowsiness, fatigue, extrapyramidal effects, parkinsonism, tardive dyskinesia, neuroleptic malignant syndrome, dizziness, endocrine disturbances, hypo- or hypertension. GI upset.

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